Why the study?
Does a fixed concentration of anticoagulant drugs produce a uniform pharmacodynamic effect on thrombin generation in healthy subjects?
Population
Platelet-poor plasma from 44 apparently healthy subjects
Comparison
Fixed concentrations of direct and… vs Baseline (before inhibition)
Design
Preclinical
Authors
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Fixed anticoagulant concentrations variably inhibit thrombin generation in animals; leaves open whether dosing uniformity holds in humans.
Does a fixed concentration of anticoagulant drugs produce a uniform pharmacodynamic effect on thrombin generation in healthy subjects?
Fixed concentrations of various anticoagulants cause highly variable inhibition of thrombin generation among individuals, challenging the assumption of predictable pharmacodynamics with standard dosing.
Bloemen et al. (2012) studied this question.
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