Why the study?
Does oral L-citrulline supplementation raise plasma L-arginine concentration and augment NO-dependent signalling?
Does oral L-citrulline supplementation raise plasma L-arginine concentration and augment NO-dependent signalling?
Oral L-citrulline supplementation effectively raises plasma L-arginine levels and enhances nitric oxide signaling in a dose-dependent manner.
Supports dose-guided NO enhancement in vascular care; extends RCT evidence for precursor-based interventions.
Our data show for the first time that oral L-citrulline supplementation raises plasma L-arginine concentration and augments NO-dependent signalling in a dose-dependent manner.
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Schwedhelm et al. (2007) studied this question.
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