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October 4, 2014FEBS Journal

Stereospecific mechanism of DJ‐1 glyoxalases inferred from their hemithioacetal‐containing crystal structures

Dongwook Choi Jihong Kim Sura Ha Kyu Kwon Eun‐Hee Kim Hee‐Yoon Lee Kyoung‐Seok Ryu Chankyu Park

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Abstract

Structural data have been submitted to the Protein Data Bank under accession numbers 4OFW (structure of atDJ-1d), 4OGF (structure of hDJ-1 with glyoxylate) and 4OGG (structure of atDJ-1d with glyoxylate).

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Choi et al. (2014) studied this question.

synapsesocial.com/papers/69db32f13d9adb00e76847cd https://doi.org/10.1111/febs.13085

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The formation of methylglyoxal from triose phosphatesIn Vitro Study · 1993 · 569 citations
2Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by GlucoseOriginal Research · 1995 · 595 citations
3Mechanism of Protein Modification by Glyoxal and Glycolaldehyde, Reactive Intermediates of the Maillard ReactionOriginal Research · 1995 · 576 citations
4Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.Original Research · 1994 · 699 citations
5Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications.Original Research · 1992 · 280 citations

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The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life1990

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