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April 9, 2026Neurology

Neurovascular Unit Dysfunction and Cerebral Small Vessel Disease in Parkinson Disease

Dylan Del Papa Jessica Herman Aidan Theepura Kunju Tara Najafi Ryan O'Boyle Adam Salama Layal Hneiny Thilani Samarakoon Taylor Peabody Sarah Marmol Matthew Feldman Ihtsham U. Haq

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Key Points

This analysis aims to explore the relationship between neurovascular unit dysfunction and cerebral small vessel disease in Parkinson Disease.
Analyzed the association between Parkinson Disease and white matter hyperintensities (WMH).
Examined midbrain enlarge perivascular spaces (ePVS) in relation to Parkinson Disease.
Assessed pooled differences in cerebral microbleeds (CMB) and lacunes.
Parkinson Disease showed a greater burden of WMH.
Increased midbrain ePVS was associated with Parkinson Disease.
No significant pooled differences in CMB and lacunes were found.

Implication

Analysis associates neurovascular unit dysfunction with greater WMH burden in Parkinson Disease, indicating potential cognitive risks.

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Cite This Study

Papa et al. (2026) studied this question.

synapsesocial.com/papers/69db365c4fe01fead37c4758 https://doi.org/10.1212/wnl.0000000000214873

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cerebral small vessel disease may not critically influence familial Parkinson’s disease2024
2Structural abnormalities in gray matter, white matter, and cerebrospinal fluid in parkinson’s disease: a voxel-based morphometry studyOriginal Research · 2026
3Impact of White Matter Hyperintensities Spatial Location on Cognition in Parkinson’s DiseaseMeta-Analysis · 2025
4Quantitative Analysis of Automatically Segmented Perivascular Space in Subcortical White Matter of Parkinson’s Disease: Its Clinical RelevanceCohort Study · 2026
5Neuroanatomical changes in early Parkinson’s disease with mild cognitive impairment: gray matter and white matter damage2025 · 5 citations