Challenging diagnosis: prolidase deficiency presenting as nonhealing ulcers and pancytopenia complicated by gluten enteropathy—a case report

Key Points

• To emphasize the significance of recognizing prolidase deficiency in patients presenting with chronic ulcers and blood count abnormalities.
• Descriptive case report detailing the patient's clinical presentation and diagnostic journey.
• Involved genetic testing to confirm prolidase deficiency.
• Reviewed the patient's response to multidisciplinary management approaches.
• Identified prolidase deficiency as the underlying condition after genetic testing confirmed the diagnosis.
• The patient exhibited chronic skin ulcers and signs of pancytopenia.
• Management strategies improved the patient's condition, highlighting the benefit of early diagnosis.