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April 12, 2026International Journal of Infectious DiseasesOpen Access

Investigating prognostic classifications of pre-existing multiple long-term conditions for health outcomes one-year after COVID-19 hospitalisation: a UK prospective observational study

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Authors

LGLucy GardinerNIHR Leicester Biomedical Research CentreDLDaniel Lozano-RojasNIHR Leicester Biomedical Research CentreNSNikki SmithLeicester City Council

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Implication

Observational study investigates health outcomes one year after COVID-19 in adults with multiple long-term conditions, indicating significant recovery challenges.

Key Points

  • This research aims to explore the impact of pre-existing multiple long-term conditions on health outcomes one year after COVID-19 hospitalization.
  • Recruitment of adults post-COVID-19 hospitalization in 2020-2021.
  • Comparison of one-year recovery using multivariable logistic regression.
  • 1:1 propensity matching for age, sex, ethnicity, and additional factors.
  • Assessment of MLTC categorization and co-occurrence patterns via latent class analysis.
  • Adults with MLTCs had lower odds of feeling fully recovered (OR 0.66).
  • Recovery was more negatively impacted by the type of body systems involved than the number of conditions.
  • Four distinct latent classes of MLTCs were identified, each associated with varying recovery risks.

Cite This Study

Gardiner et al. (2026) studied this question.

synapsesocial.com/papers/69db365c4fe01fead37c48bchttps://doi.org/10.1016/j.ijid.2026.108695
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