Key result
Age, obesity, and CAD linked to ~68% higher new-onset AF risk in dialysis patients.
Why the study?
Atrial fibrillation is a prevalent cardiovascular complication in end-stage renal disease patients, but its specific predictors in this population remain poorly understood.
Cohort (n=5,326)
Yes
Effect estimate: OR 1.678 (95% CI 1.466-1.920)
p-value: p=<0.0001
Age, obesity, and coronary artery disease are significant predictors of new-onset atrial fibrillation in end-stage renal disease patients on dialysis.
Background/Objectives: Atrial fibrillation (AF) is a significant and prevalent cardiovascular complication in end-stage renal disease (ESRD) patients, yet its specific predictors within this population are not well understood. This study aimed to identify the predictors of new-onset AF in ESRD patients undergoing dialysis. Methods: We conducted a retrospective multicenter cohort study within the Northwell Health System, analyzing data from 5326 ESRD patients on dialysis between 2017 and 2019. The mean age was 64.2 ± 13.1 years, with 48.3% females. Multivariable-adjusted logistic regression was used to identify predictors of new-onset AF, the primary outcome. Adjusted odds ratios (ORs) were calculated for potential risk factors. Results: Of the 5326 patients, 1564 (29.4%) developed new-onset AF. Significant predictors included increasing age (OR 1.038 per year, 95% CI 1.032–1.044, p < 0.0001), obesity (BMI > 30 vs. BMI 20–25: OR 1.208, 95% CI 1.026–1.422, p = 0.023), and coronary artery disease (OR 1.678, 95% CI 1.466–1.920, p < 0.0001). African American patients had lower odds of developing AF compared to White patients (OR 0.578, 95% CI 0.494–0.676, p < 0.0001). Hypertension, sex, diabetes, and tobacco use were not significantly associated with AF risk. Conclusions: Age, obesity, and coronary artery disease are significant predictors of new-onset AF in ESRD patients on dialysis. Notable racial disparities exist, with African American patients having a lower risk. These findings may inform targeted prevention strategies and guide future research into the mechanisms underlying AF in ESRD patients.
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Zayed et al. (2026) conducted a cohort in End-stage renal disease (n=5,326). Risk factors (age, obesity, coronary artery disease) was evaluated on New-onset atrial fibrillation (OR 1.678, 95% CI 1.466-1.920, p=<0.0001). Increasing age, obesity, and coronary artery disease (OR 1.678; 95% CI 1.466-1.920) were significant predictors of new-onset atrial fibrillation in end-stage renal disease patients on dialysis.
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