Tirzepatide as an Add-on for Participants with Inadequate Glycemic Control Using Basal Insulin: Pooled Subgroup Analysis of SURPASS-5 and -6

Harpreet S. Bajaj; Liana K. Billings; Palash Sharma; Joshua A. Levine; Angel Rodriguez; Hiren N. Patel

doi:10.1007/s13300-026-01859-3

April 10, 2026Diabetes TherapyOpen Access

Tirzepatide as an Add-on for Participants with Inadequate Glycemic Control Using Basal Insulin: Pooled Subgroup Analysis of SURPASS-5 and -6

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Key Points

Evaluate the efficacy of tirzepatide as an add-on therapy for individuals with inadequate glycemic control on basal insulin.
Pooled analysis of data from SURPASS-5 and SURPASS-6 trials
Participants previously using basal insulin with inadequate glycemic control
Comparison of glycemic outcomes between treatment and control groups
Tirzepatide significantly improved glycemic control compared to placebo
Participants experienced a reduction in HbA1c levels
Enhanced outcomes were observed across various subgroups of participants

Implication

Pooled subgroup analysis demonstrates improved glycemic control with tirzepatide in individuals using basal insulin, suggesting enhanced treatment options.

Abstract

Trials were registered at ClinicalTrials.gov under the identifiers NCT04039503 (SURPASS-5) and NCT04537923 (SURPASS-6).

Discussion

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Cite This Study

Bajaj et al. (2026) studied this question.

synapsesocial.com/papers/69db36e64fe01fead37c4cf5 https://doi.org/10.1007/s13300-026-01859-3

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Tirzepatide as an Add-on for Participants with Inadequate Glycemic Control Using Basal Insulin: Pooled Subgroup Analysis of SURPASS-5 and -6

Key Points

Implication

Abstract

Discussion

Cite This Study

Tirzepatide as an Add-on for Participants with Inadequate Glycemic Control Using Basal Insulin: Pooled Subgroup Analysis of SURPASS-5 and -6

Key Points

Implication

Abstract

Discussion

Cite This Study

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