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April 10, 2026Epigenomics

Longitudinal study of genome-wide DNA methylation in individuals with and without post-acute symptoms following SARS-CoV-2 infection

Jon Bohlin Yunsung Lee Ida Henriette Caspersen Anna Hayman Robertson Christian M. Page H kon K. Gjessing Astanand Jugessur Per Magnus Siri Mjaaland Lill Trogstad

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Key Points

This study aims to investigate epigenetic changes related to long-COVID and SARS-CoV-2 infection in different cohorts.
Conducted a longitudinal analysis
Examined genome-wide DNA methylation
Compared individuals with and without post-acute symptoms
No persistent epigenetic age differences were found
No DNA methylation differences detected in cohorts due to long-COVID

Implication

Longitudinal study investigates epigenetic differences post-SARS-CoV-2 infection, suggesting no significant changes in symptoms.

Abstract

No persistent epigenetic age- or DNAm based differences due to Long-COVID or SARS-CoV-2 infection were detected in our cohorts.

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Cite This Study

Bohlin et al. (2026) studied this question.

synapsesocial.com/papers/69db36e64fe01fead37c4d2b https://doi.org/10.1080/17501911.2026.2656361

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Differential DNA methylation 7 months after SARS-CoV-2 infectionCase-Control Study · 2025 · 8 citations
2Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study2024 · 24 citations
3DNA methylation in long COVID2024 · 7 citations
4DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients’ airway epithelial cellsOriginal Research · 2026
5Whole-genome DNA methylation profiling in COVID-19 positive patients reveals alterations in pathways linked to neurological dysfunction2025

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Epigenetic ageing during the COVID-19 pandemic: global age acceleration, independent of SARS-CoV-2 infection2026

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