A case report demonstrates soluble A antigen affecting blood type in a hematopoietic stem cell transplant patient, suggesting implications for transfusion practices.
We present a case of persistent A antigen post-ABOi HSCT due to soluble A antigen of patient origin. Soluble A antigen was demonstrated using adsorption, neutralization studies, and a modified elution method previously described for Lewis antigens. This case suggests increased soluble ABO antigen in the setting of gut GVHD.
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Hugan et al. (2026) studied this question.
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