This research investigates the impact of cannabinoid receptor type 2 (CB2R) on behavior and neuronal health in male mice with graft versus host disease.
Deletion of CB2R in recipient mice
Assessment of neuronal loss
Evaluation of behavioral responses during disease progression
CB2R deletion protects against neuronal loss in the brain
These data indicate that while CB2R deletion from the recipient mice protects against neuronal loss and inflammation in the brain, it does not protect against acute behavioral dysregulation.