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January 1, 2026Einstein (São Paulo)Open Access

Preliminary diagnostic criteria for distinguishing metaplastic Warthin tumors from mucoepidermoid carcinomas rich in lymphoid stroma

João Felipe Leite Bonfitto João Figueira Scarini Iara Vieira Ferreira Reydson Alcides De Lima-Souza Erika Said Abu Egal Albina Altemani Fernanda Viviane Mariano

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Key Points

The study aims to evaluate clinicopathological and immunohistochemical profiles to differentiate between unconventional Warthin tumors and mucoepidermoid carcinomas.
Analyzed eleven low-grade salivary gland tumors with Warthin-like features.
Grouped tumors into two categories based on epithelial structures.
Examined immunohistochemical staining patterns for various markers.
Immunohistochemistry effectively distinguished Warthin-like mucoepidermoid carcinoma from metaplastic Warthin tumor.
Key markers included CK7 and mitochondrial patterns suggesting metaplastic Warthin tumor presence.
Basal CK14, CK5/6, and p63 helped differentiate these tumors with specificity.

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Implication

Analyzes immunohistochemical features to distinguish Warthin tumors from mucoepidermoid carcinomas, suggesting important diagnostic criteria.

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Cite This Study

Bonfitto et al. (2026) studied this question.

synapsesocial.com/papers/69db37b04fe01fead37c5c52 https://doi.org/10.31744/einstein_journal/2026ao1591

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