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January 1, 2026Chemical CommunicationsOpen Access

Next-generation multimetal complex induces immunogenic cell death with distinct transcriptomic signatures

Tomer Babu Matthew S. Levine Bingsong Zeng Jonathan L. Sessler

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Key Points

The study aims to evaluate the effect of a Pt(IV)–Au(I)-gemcitabine prodrug on inducing immunogenic cell death in cancer cells.
Developed a Pt(IV)–Au(I)-gemcitabine prodrug
Evaluated cytotoxicity in cancer cell lines
Assessed transcriptomic signatures after treatment
The prodrug shows enhanced cytotoxicity compared to individual components
Induces distinct transcriptomic changes linked to immunogenic cell death
Demonstrates improved efficacy in stress-related cellular conditions.

Implication

Next-generation multimetal complex induces immunogenic cell death in cancer cells, suggesting a novel therapeutic approach.

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Cite This Study

Babu et al. (2026) studied this question.

synapsesocial.com/papers/69db37df4fe01fead37c5fa3 https://doi.org/10.1039/d6cc01066k

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Three Is Better than One: A Multimetal Complex that Triggers Immunogenic Cell Death2025 · 7 citations
2Three Is Better than One: A Multimetal Complex that Triggers Immunogenic Cell Death.2025 · 10 citations
3A New Class of Gold(I) NHC Complexes with Proapoptotic and Resensitizing Properties towards Multidrug Resistant Leukemia Cells Overexpressing BCL-22024 · 17 citations
4Uncoupling tumor immunogenicity from cell death with platinum(IV)-antibody conjugatesOriginal Research · 2026 · 6 citations
5Oxaliplatin(IV) Prodrugs Functionalized with Gemcitabine and Capecitabine Induce Blockage of Colorectal Cancer Cell Growth—An Investigation of the Activation Mechanism and Their Nanoformulation2024 · 9 citations

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