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WHO recommends methadone or buprenorphine to treat opioid use disorder, suggesting improved health outcomes globally.
The World Health Organization (WHO) has called on treatment providers worldwide to rely on two treatments for opioid use disorder (OUD): methadone and buprenorphine. Worldwide, OUD is a major contributor to morbidity and mortality. According to WHO, of 600,000 deaths attributed to drug use, about 450,000 are due to opioid use.
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Alison Knopf (2026) studied this question.
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