This research reveals how oral nanoparticles restore immune function, enhancing vaccine efficacy in aging mice, indicating new therapeutic avenues.
Aging impairs vaccine responses. Dai et al. reported that defective cDC2 migration in immunized old mice, diminishing humoral and cellular immunity. Oral yeast-derived nanoparticles restore DC migration and vaccine efficacy. These findings establish impaired DC migration as a key mechanism of age-related immune decline, introducing a noninvasive strategy to correct immunosenescence.
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Zhao et al. (2026) studied this question.
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