Case-control fMRI study reveals specific memory network disruptions in transient global amnesia, suggesting limbic dysconnectivity.
TGA is associated with transient, selective hypoconnectivity within the mesiotemporal-cingulate episodic memory network, aligning with previous reports and further precising the functional anatomy. The finding of a profound anterograde amnesia was replicated and its recovery timecourse was elucidated. Semantic memory and metamemory remain preserved, clarifying inconsistencies in prior reports. These findings suggest that TGA reflects a transient limbic dysconnectivity syndrome rather than a diffuse network disorder, reconciling structural lesions with clinical and functional data.
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Otmani et al. (2026) studied this question.
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