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April 12, 2026Journal of Neurology0 citationsOpen Access

Plasma neurofilament light chain and glial fibrillary acidic protein in the differential diagnosis of acute vertigo in the emergency department

MHMelanie HaideggerMedical University of Graz NBNatalie BergerMedical University of Graz SFSimon Fandler-HöflerMedical University of Graz

Key Points

The aim is to evaluate the diagnostic role of plasma neurofilament light chain and glial fibrillary acidic protein in distinguishing the causes of acute vertigo.
Measured pNfL and pGFAP levels in patients presenting with acute vertigo.
Compared biomarker levels between patients with potential central causes vs. non-central causes.
Analyzed negative predictive value of pNfL.
Found significantly higher levels of pNfL and pGFAP in patients with potential central causes of vertigo (PCS).
Demonstrated that pNfL has a high negative predictive value for ruling out PCS in acute vertigo cases.

Abstract

pNfL and pGFAP levels were higher in PCS compared to patients with non-central causes of vertigo. With its high negative predictive value, pNfL appears especially clinically useful to rule out PCS in acute vertigo.

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Haidegger et al. (Fri,) studied this question.

synapsesocial.com/papers/69db383b4fe01fead37c6826 https://doi.org/https://doi.org/10.1007/s00415-026-13799-w

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