Why the study?
Is resting cardiac autonomic control altered in individuals with Down syndrome compared to healthy controls?
Is resting cardiac autonomic control altered in individuals with Down syndrome compared to healthy controls?
Individuals with Down syndrome exhibit reduced resting heart rate variability indicative of autonomic dysfunction, which does not appear to correlate with fitness level or obesity.
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Reduced HRV in Down syndrome suggests autonomic dysfunction independent of fitness or BMI; leaves open cardiovascular risk implications.
Our goal in this study was to compare cardiac autonomic control at rest between 50 individuals with Down syndrome and 24 control participants without disabilities. Resting autonomic function was assessed using analysis of heart rate variability. Participants with Down syndrome had reduced total heart rate variability, which indicates possible autonomic dysfunction in this population. Their VO2 peak and BMI were not significantly correlated with resting cardiac autonomic control. This may suggest that fitness level and obesity differentially affect cardiac autonomic control in persons with Down syndrome compared to their healthy, nondisabled peers.
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Goulopoulou et al. (2005) studied this question.
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