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Our data indicate that targeting Src with PP2 protected against cartilage destruction in an OA mouse model by inhibiting Wnt/β-catenin and activating TGF-β/Smad signaling, suggesting that Src may be a potential therapeutic target for OA treatment.
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Hao Zhang
Affiliated Hospital of Youjiang Medical University for Nationalities
Chuanchuan Zheng
Youjiang Medical College for Nationalities
Wei C.
Wenzhou Medical University
International Immunopharmacology
Shanghai Jiao Tong University
Dongguan University of Technology
Third Affiliated Hospital of Southern Medical University
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Zhang et al. (Wed,) studied this question.
synapsesocial.com/papers/69db72040d8d6ef495a3d5a4 — DOI: https://doi.org/10.1016/j.intimp.2023.110948