Does ACE2 deficiency impair cerebrovascular function in adult mice?
ACE2 deficiency and oxidative stress contribute to cerebrovascular endothelial dysfunction during aging in mice.
ACE2 deficiency impaired endothelial function in cerebral arteries from adult mice and augmented endothelial dysfunction during aging. Oxidative stress plays a critical role in cerebrovascular dysfunction induced by ACE2 deficiency and aging.
Silva et al. (Sat,) studied this question.
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