Why the study?
Does oral alcohol intake depress chemoreflex sensitivity in normal male subjects?
Population
16 normal male subjects
Comparison
Oral alcohol intake (1.0 g/kg body weight) vs Vehicle
Design
RCT, randomized, double-blind
Follow-up
85 minutes
Authors
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Acute alcohol does not depress chemoreflex sensitivity in healthy men; challenges this mechanism for sleep apnea exacerbation and directs research to alternatives.
Does oral alcohol intake depress chemoreflex sensitivity in normal male subjects?
Acute alcohol intake increases heart rate and sympathetic nerve activity but does not alter chemoreflex responses to hypoxia or hypercapnia, suggesting other mechanisms explain its exacerbation of sleep apnea.
Borne et al. (1997) studied this question.
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