Why the study?
Does ethanol ingestion and subsequent naloxone administration affect the ventilatory response to hypercapnic hypoxia differently in males and females?
Population
16 normal subjects (8 males and 8 females)
Comparison
Ethanol ingestion followed by intravenously… vs Baseline/control responses without ethanol
Authors
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May indicate sex-specific alcohol effects on hypoxic ventilation; hypothesis-generating and leaves open opioid mediation pending replication.
Does ethanol ingestion and subsequent naloxone administration affect the ventilatory response to hypercapnic hypoxia differently in males and females?
Ethanol depresses hypoxic ventilatory responsiveness in males but not females, an effect that appears to be mediated by opioid-like mechanisms as it is reversed by naloxone.
McCauley et al. (1988) studied this question.
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