Reveals CPAP does not prevent cardiovascular events in sleep apnea and heart disease, highlighting limited secondary preventive benefit.
Therapy with CPAP plus usual care, as compared with usual care alone, did not prevent cardiovascular events in patients with moderate-to-severe obstructive sleep apnea and established cardiovascular disease. (Funded by the National Health and Medical Research Council of Australia and others; SAVE ClinicalTrials.gov number, NCT00738179 ; Australian New Zealand Clinical Trials Registry number, ACTRN12608000409370 .).
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McEvoy et al. (2016) studied this question.
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