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It has been challenging to detect small analytes in both positive and negative ion modes using organic matrices in conventional matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Herein, TiO₂ nanowires are presented as a solid matrix to form dual ions of analytes regardless of their chemical properties and to demonstrate versatile applicability in LDI-MS.
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Kim et al. (2020) studied this question.
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