Identifies miR-130b-3p in adipocyte-derived small extracellular vesicles as a mediator of exacerbated myocardial ischemia/reperfusion injury in diabetes.
We demonstrate for the first time that miR-130b-3p enrichment in dysfunctional adipocyte-derived sEV, and its suppression of multiple antiapoptotic/cardioprotective molecules in cardiomyocytes, is a novel mechanism exacerbating MI/R injury in the diabetic heart. Targeting miR-130b-3p mediated pathological communication between dysfunctional adipocytes and cardiomyocytes may be a novel strategy attenuating diabetic exacerbation of MI/R injury.
Gan et al. (Fri,) studied this question.