Does the addition of GDF-15 measurement on admission to the GRACE score improve risk estimation in patients with non-ST-elevation acute coronary syndrome?
Adding a single GDF-15 measurement on admission to the GRACE score improves risk stratification in patients with non-ST-elevation acute coronary syndrome.
We show that a single measurement of GDF-15 on admission markedly enhances the predictive value of the GRACE score and provides moderate incremental information to a model including the GRACE score and NT-proBNP. Our study is the first to provide simple algorithms that can be used by the practicing clinician to more precisely estimate risk in individual patients based on the GRACE score and a single biomarker measurement on admission. The rigorous statistical approach taken in the present study may serve as a blueprint for future studies exploring the added value of biomarkers beyond clinical risk scores.
Widera et al. (Fri,) studied this question.