The transcriptional identity of cardiac fibroblasts and their contribution to cardiac repair offer a novel perspective for reinterpreting cardiac regenerative therapies.
No immediate change to clinical heart failure care; leaves open whether fibroblast reprogramming can enhance human cardiac regeneration.
The surprising transcriptional identity of cardiac fibroblasts, the adoption of cardiogenic gene programs, and direct contribution to cardiac development and repair provoke alternative interpretations for studies on more specialized cardiac progenitors, offering a novel perspective for reinterpreting cardiac regenerative therapies.
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Furtado et al. (2014) studied this question.
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