STEMI triggers the mobilization of specific stem and progenitor cells into peripheral blood, a process in which stromal cell-derived factor-1 plays an important role.
Hypothesis-generating for SDF-1 in post-STEMI progenitor mobilization; leaves open therapeutic targeting and should not change practice.
The study demonstrates in the setting of STEMI a marked mobilization of mononuclear cells expressing specific cardiac, muscle, and endothelial markers as well as CD34/CXCR4+ and CD34/CD117+ and c-met+ stem cells and shows that stromal cell-derived factor-1 is an important factor influencing the mobilization.
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Wojakowski et al. (2004) studied this question.
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