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May 4, 1990Science331 citations

K + Current Diversity Is Produced by an Extended Gene Family Conserved in Drosophila and Mouse

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Population

Drosophila and mouse models (genes encoding voltage-gated potassium channels)

Design

Preclinical

Authors

AWAguan WeiMCManuel CovarrubiasABAlice Butler

Discussion

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Overview

Hypothesis-generating for cardiac K+ channel diversity; leaves open specific roles of mammalian homologs in arrhythmias.

Structured PICO

P
Population
Drosophila and mouse models (genes encoding voltage-gated potassium channels)
O
Outcome
Characterization of potassium channel kinetics and voltage sensitivity

Identifies an extended family of potassium channel genes conserved across Drosophila and mammals, explaining the diversity of potassium currents.

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Cite This Study

Wei et al. (1990) studied this question.

synapsesocial.com/papers/69dbc0659e6f14d6f16840fchttps://doi.org/10.1126/science.2333511
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