January 1, 2015Chemical ScienceOpen Access

Invader probes: harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications

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Abstract

Optimized Invader probes enable efficient (C₅₀ < 1 μM), fast (t₅₀ < 3 h), kinetically stable (>24 h), and single nucleotide specific recognition of DNA targets.

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Cite This Study

Guenther et al. (2015) studied this question.

synapsesocial.com/papers/69dbc4fe78a3e0e288685878 https://doi.org/10.1039/c5sc01238d

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Abstract

Optimized Invader probes enable efficient (C₅₀ < 1 μM), fast (t₅₀ < 3 h), kinetically stable (>24 h), and single nucleotide specific recognition of DNA targets.