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April 7, 2016Knee Surgery Sports Traumatology Arthroscopy

Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options

Tahir Mutlu Duymuş Serhat Mutlu Bahar Dernek Baran Kömür Suavi Aydoğmuş Fatma Nur Kesiktaş

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Therapeutic study, Level I.

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Duymuş et al. (2016) studied this question.

synapsesocial.com/papers/69dbc82350e1971baba3cb61 https://doi.org/10.1007/s00167-016-4110-5

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Analgesic Effect of Elastoviscous Hyaluronan Solutions and the Treatment of Arthritic PainReview · 2003 · 66 citations
2Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin‐8 productionIn Vitro Study · 1998 · 127 citations
3Comparison Between Hyaluronic Acid and Platelet-Rich Plasma, Intra-articular Infiltration in the Treatment of GonarthrosisCohort Study · 2012 · 432 citations
4Platelet‐rich plasma intra‐articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritisCohort Study · 2010 · 476 citations
5Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trialRCT · 2012 · 387 citations

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Platelet-Rich Plasma Intra-articular Knee Injections Show No Superiority Versus Viscosupplementation2015
Platelet‐rich plasma: why intra‐articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration2013
The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee2014

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