All patients with PLA₂R1-associated membranous nephropathy recognize at least two epitope regions in the N- and C-terminals of PLA₂R1 at diagnosis, contradicting the hypothesis that PLA₂R1 "epitope spreading" determines the prognosis of membranous nephropathy. Total anti-PLA₂R1 antibody levels, but not the epitope-recognition profiles at the time of diagnosis, are relevant for the clinical outcome of patients with this disease.
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Reinhard et al. (2019) studied this question.
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