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November 15, 2017HepatologyOpen Access

Long noncoding RNA H19 interacts with polypyrimidine tract‐binding protein 1 to reprogram hepatic lipid homeostasis

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Design

Preclinical

Authors

CLChune LiuHeilongjiang University of Technology ZYZhihong YangGuiyang College of Traditional Chinese Medicine JWJianguo WuCleveland Clinic

Discussion

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Implication

Hypothesis-generating for H19/PTBP1/SREBP1 in fatty liver; leaves open human validation before any clinical relevance.

Structured PICO

O

Outcome

Development of fatty liver

The study identifies a novel H19/PTBP1/SREBP1 signaling pathway involved in the pathogenesis of fatty liver.

Cite This Study

Liu et al. (2017) studied this question.

synapsesocial.com/papers/69dbcc1650e1971baba3ccaa https://doi.org/10.1002/hep.29654

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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision2015 · 130 citations
2Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism2014 · 69 citations
3PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells2014 · 49 citations
4H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA2016 · 266 citations