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November 4, 2019JAMA NeurologyOpen Access

Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life

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Why the study?

Is higher vascular risk across adulthood associated with brain pathology in late life?

Population

Individuals assessed at age 69 to 71 years

Comparison

Higher vascular risk across adulthood vs lower vascular risk

Authors

CLChristopher LaneLos Alamos National LaboratoryJBJosephine BarnesUK Dementia Research InstituteJNJennifer M. NicholasUniversity of London

Discussion

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Implication

Supports early vascular risk targeting to preserve late-life brain structure; hypothesis-generating, needs prospective trials before practice change.

Structured PICO

Is higher vascular risk across adulthood associated with brain pathology in late life?

P
Population
Adults evaluated for vascular risk across adulthood and brain pathology at age 69 to 71 years
I
Intervention
Higher vascular risk (exposure)
C
Comparator
Lower vascular risk
O
Outcome
Whole-brain volume, white matter-hyperintensity volume, and amyloid deposition at age 69 to 71 yearssurrogate

Early adulthood vascular risk is strongly associated with late-life brain structural changes, highlighting the importance of early risk reduction.

Cite This Study

Lane et al. (2019) studied this question.

synapsesocial.com/papers/69dbcf0078a3e0e288685b67https://doi.org/10.1001/jamaneurol.2019.3774
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Apolipoprotein E ε4 and Vascular Disease on Brain Morphology in Men From the NHLBI Twin Study1999 · 112 citations
  2. 2Sex differences in cardiovascular ageing2016 · 288 citations
  3. 3Association Between Apolipoprotein E Genotype and Carotid Intima-Media Thickness May Suggest a Specific Effect on Large Artery Atherothrombotic Stroke2007 · 62 citations
  4. 4Cohort Profile: Updating the cohort profile for the MRC National Survey of Health and Development: a new clinic-based data collection for ageing research2011 · 309 citations