Why the study?
Are SLE patients with nephritis at higher risk of premature atherosclerosis and endothelial dysfunction compared to those without nephritis?
Are SLE patients with nephritis at higher risk of premature atherosclerosis and endothelial dysfunction compared to those without nephritis?
Flow-mediated dilation using vascular ultrasonography is a useful non-invasive method to assess endothelial dysfunction in SLE patients, who are at high risk for arterial stiffening, particularly those with nephritis.
Supports vascular monitoring in SLE nephritis; hypothesis-generating and requires prospective validation before changing practice.
SLE patients with nephritis are at a higher risk to develop arterial stiffening, leading to early end-organ damage. Early aggressive treatment may prevent endothelial dysfunction. FMD using vascular ultrasonography on the brachial artery represents a non-invasive, repeatable and useful method for the assessment of endothelial dysfunction.
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Sharma et al. (2015) studied this question.
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