Why the study?
Does verapamil or BAY K8644 affect atrial contractile dysfunction following short-term atrial fibrillation?
Does verapamil or BAY K8644 affect atrial contractile dysfunction following short-term atrial fibrillation?
Transsarcolemmal calcium influx contributes to postfibrillation atrial contractile dysfunction, which can be mitigated by calcium channel blockers like verapamil.
Should not change clinical practice; leaves open whether calcium channel blockade mitigates post-AF atrial dysfunction in humans.
Atrial contractile dysfunction after short-term atrial fibrillation is reduced by the calcium antagonist verapamil, which suggests that transsarcolemmal calcium influx contributed to this dysfunction. The calcium agonist BAY K8644 increased postfibrillation atrial contractile dysfunction. Atrial ischemia was not observed during fibrillation.
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Leistad et al. (1996) studied this question.
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