Genetic deficiency of PAI-1 in aged mice promotes cardiac fibrosis, potentially linking endothelial-to-mesenchymal transition and TGF-β signaling.
PAI-1 deficiency may promote cardiac fibrosis via TGF-β in aged mice; hypothesis-generating and should not change clinical practice.
These results indicate that spontaneous activation of both Smad and non-Smad transforming growth factor-β signaling may contribute to profibrotic responses in aged PAI-1-deficient mice hearts and establish a possible link between endothelial-to-mesenchymal transition and cardiac fibrosis in PAI-1-deficient mice.
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Ghosh et al. (2010) studied this question.
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