January 1, 2007BMC Medical Genetics138 citationsOpen Access
Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
Structured PICO
Are specific genetic variants (SNPs) associated with subclinical atherosclerosis phenotypes in major arterial territories?
P
Population
Participants in the NHLBI's Framingham Heart Study
I
Intervention
Single nucleotide polymorphisms (SNPs)
O
Outcome
Subclinical atherosclerosis (SCA) phenotypes in multiple arterial bedssurrogate
This genome-wide association study identified candidate genetic variants potentially linked to subclinical atherosclerosis across multiple arterial beds, providing targets for future replication studies.
Abstract
The results from this GWAS generate hypotheses regarding several SNPs that may be associated with SCA phenotypes in multiple arterial beds. Given the number of tests conducted, subsequent independent replication in a staged approach is essential to identify genetic variants that may be implicated in atherosclerosis.