Why the study?
Are specific genetic variants (SNPs) associated with subclinical atherosclerosis phenotypes in major arterial territories?
Are specific genetic variants (SNPs) associated with subclinical atherosclerosis phenotypes in major arterial territories?
This genome-wide association study identified candidate genetic variants potentially linked to subclinical atherosclerosis across multiple arterial beds, providing targets for future replication studies.
These SNPs are hypothesis-generating and should not change practice; leaves open confirmation of multi-bed genetic links.
The results from this GWAS generate hypotheses regarding several SNPs that may be associated with SCA phenotypes in multiple arterial beds. Given the number of tests conducted, subsequent independent replication in a staged approach is essential to identify genetic variants that may be implicated in atherosclerosis.
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O’Donnell et al. (2007) studied this question.