Why the study?
Does gut-dependent microbial translocation induce inflammation and cardiovascular events after ST-elevation myocardial infarction?
Does gut-dependent microbial translocation induce inflammation and cardiovascular events after ST-elevation myocardial infarction?
This study provides the first evidence that gut-dependent microbial translocation drives inflammation and cardiovascular events post-STEMI, suggesting the gut barrier as a novel therapeutic target.
Hypothesis-generating for gut barrier as post-MI target; should not change practice without randomized confirmation.
Our results provide the first evidence that cardiovascular outcomes post-MI are driven by intestinal microbiota translocation into systemic circulation. New therapeutic strategies targeting to protect the gut barrier and eliminate gut bacteria translocation may reduce or even prevent cardiovascular events post-MI.
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Zhou et al. (2018) studied this question.
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