Why the study?
Do elevated free fatty acid levels induce cardiac dysfunction and alter insulin signaling pathways?
Do elevated free fatty acid levels induce cardiac dysfunction and alter insulin signaling pathways?
Elevated free fatty acids may contribute to cardiac dysfunction by inducing myocardial insulin resistance and altering PI3K-Akt-GLUT4 and AMPK-eNOS signaling pathways.
Warrants caution with elevated FFAs in at-risk cardiac patients; leaves open whether FFA reduction improves myocardial insulin signaling in humans.
Elevated FFA levels may impair cardiac function and cardiac dysfunction might result from myocardial insulin resistance with significant changes to PI3K-Akt-GLUT4 and AMPK-eNOS signaling pathways with increasing FFA levels.
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Han et al. (2018) studied this question.
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