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February 1, 2009Journal of Periodontology

Levels of Interferon‐Gamma and Transcription Factor T‐Bet in Progressive Periodontal Lesions in Patients With Chronic Periodontitis

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Authors

NDNicolás DutzanUniversidad de Santiago de Chile RVRolando VernalFundação Faculdade de Odontologia MHMarcela HernándezUniversidad de Santiago de Chile

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Implication

Observational study reveals increased IFN-gamma and T-bet expression in chronic periodontitis patients, indicating a pathway driving progressive tissue breakdown.

Key Points

To examine the levels of cytokine interferon-gamma (IFN-gamma) and transcription factor T-bet in progressive periodontal lesions among individuals with chronic periodontitis.
Measured total amount and concentration of IFN-gamma in gingival crevicular fluid (GCF) samples.
Assessed transcription factor T-bet expression profiles in progressive periodontal tissue lesions.
Total amount and concentration of IFN-gamma were increased in GCF samples from progressive periodontal lesions.
Transcription factor T-bet expression was elevated in progressive lesions compared to non-progressive sites.

Cite This Study

Dutzan et al. (2009) studied this question.

synapsesocial.com/papers/69dbeacef7e0c66ced836dca https://doi.org/10.1902/jop.2009.080287

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Implication

Observational study reveals increased IFN-gamma and T-bet expression in chronic periodontitis patients, indicating a pathway driving progressive tissue breakdown.

Levels of Interferon‐Gamma and Transcription Factor T‐Bet in Progressive Periodontal Lesions in Patients With Chronic Periodontitis

Discussion

Member takes

Implication

Key Points

Cite This Study

Levels of Interferon‐Gamma and Transcription Factor T‐Bet in Progressive Periodontal Lesions in Patients With Chronic Periodontitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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