Why the study?
Peak oxygen consumption is reduced in breast cancer survivors and predicts increased cardiovascular and all-cause mortality, but the underlying mechanisms remain unclear.
Does body composition deterioration or impaired skeletal muscle bioenergetics contribute to reduced exercise tolerance in anthracycline-treated breast cancer survivors?
Population
Anthracycline-treated breast cancer survivors 1 year after anthracycline therapy
Follow-up
1 year after anthracycline therapy
Authors
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Body composition deterioration may drive reduced exercise tolerance after anthracyclines; hypothesis-generating for lifestyle interventions and requires prospective confirmation.
Does body composition deterioration or impaired skeletal muscle bioenergetics contribute to reduced exercise tolerance in anthracycline-treated breast cancer survivors?
Reduced exercise tolerance in anthracycline-treated breast cancer survivors appears to be driven by body composition deterioration rather than impaired skeletal muscle bioenergetics or oxygenation, highlighting the potential value of lifestyle interventions.
Beaudry et al. (2020) studied this question.
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