Previous studies have only partially characterized the road-accident risks linked to driving while taking opioid analgesics used for moderate pain.1,2,3,4 A prospective cohort design with data from national population–based registries—the Norwegian Prescription Database and the Norwegian Road Accident Registry—and observation of >8 million person-years were used in order to examine whether a driver who has filled a prescription for codeine or tramadol is at increased risk of being involved in a road accident resulting in injury to persons. Clinical Pharmacology & Therapeutics (2009); 85, 6, 596–599 doi:10.1038/clpt.2009.14
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Bachs et al. (2009) studied this question.
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