What question did this study set out to answer?

To outline the feasibility and primary challenges of identifying structural, non-chromosomal fetal abnormalities during early ultrasound examinations at 11–13 weeks.

January 1, 2011Prenatal Diagnosis

Challenges in the diagnosis of fetal non‐chromosomal abnormalities at 11–13 weeks

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To outline the feasibility and primary challenges of identifying structural, non-chromosomal fetal abnormalities during early ultrasound examinations at 11–13 weeks.
Evaluated the anatomical detectability of structural fetal anomalies during first-trimester ultrasound screening at 11–13 weeks of gestation.
Assessed diagnostic capability relative to nuchal translucency thickness, gestational changes in phenotypic presentation, and predetermined examination objectives.
Certain structural anomalies are reliably detectable at 11–13 weeks, whereas a distinct subset can never be identified at this early gestational age.
A substantial portion of non-chromosomal abnormalities remains potentially detectable depending on associated nuchal translucency enlargement, dynamic fetal phenotype progression, and specific screening protocols.

Implication

Clinical review demonstrates variable detection of non-chromosomal abnormalities in first-trimester fetuses, highlighting the influence of gestational timing and scan objectives.

Abstract

At 11-13 weeks some abnormalities are always detectable, some can never be and others are potentially detectable depending on their association with increased NT, the phenotypic expression of the abnormality with gestation and the objectives set for such a scan.

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Cite This Study

Syngelaki et al. (2011) studied this question.

synapsesocial.com/papers/69dc2f2045b398e6439f5476 https://doi.org/10.1002/pd.2642

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Implication

Clinical review demonstrates variable detection of non-chromosomal abnormalities in first-trimester fetuses, highlighting the influence of gestational timing and scan objectives.

Challenges in the diagnosis of fetal non‐chromosomal abnormalities at 11–13 weeks

Key Points

Implication

Abstract

Discussion

Cite This Study

Challenges in the diagnosis of fetal non‐chromosomal abnormalities at 11–13 weeks

Key Points

Implication

Abstract

Discussion

Cite This Study

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