Readily accessible β,γ-unsaturated ketoximes reacted with 2-arylphenylisonitriles under the conditions of t-BuOOH and n-Bu4NI to give isoxazoline functionalized phenanthridines via tandem intramolecular/intermolecular C-O/C-C/C-C bond formation. The reaction involves the initial generation of iminoxyl radicals from the oxidation of β,γ-unsaturated ketoximes by t-BuOOH and n-Bu4NI followed a cascade radical cyclization/addition/cyclization sequence.
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Yang et al. (2014) studied this question.
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