Why the study?
Does tautomycin inhibit protein phosphatases and induce contraction in smooth muscle fibers?
Population
Intact and permeabilized smooth muscle fibers and chicken gizzard actomyosin
Design
Preclinical
Authors
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May aid basic smooth muscle research; leaves open cardiovascular translation.
Does tautomycin inhibit protein phosphatases and induce contraction in smooth muscle fibers?
Tautomycin is a potent inhibitor of type-1 and type-2A protein phosphatases that induces Ca(2+)-independent contraction in smooth muscle fibers, making it a valuable tool for studying protein phosphorylation.
Hori et al. (1991) studied this question.
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