What question did this study set out to answer?

Identify biological correlates of protection against SARS-CoV-2 breakthrough infection and determine factors reducing symptomatic disease intensity among vaccinated individuals exposed in household settings.

March 21, 2023The Lancet MicrobeOpen Access

Correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel (ICoFS): a prospective cohort study

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Identify biological correlates of protection against SARS-CoV-2 breakthrough infection and determine factors reducing symptomatic disease intensity among vaccinated individuals exposed in household settings.
Conducted a prospective cohort study (ICoFS) monitoring vaccinated individuals exposed to confirmed SARS-CoV-2 cases in Israel.
Collaborated with the Israeli Ministry of Health to evaluate infection rates and clinical symptom severity following household exposure.
Identified circulating immune markers associated with a reduced probability of acquiring breakthrough SARS-CoV-2 infection after household exposure.
Demonstrated that elevated protective immune responses correlate with attenuated intensity of symptomatic disease in breakthrough cases.

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Implication

Prospective cohort study observes correlates of protection in vaccinated household contacts, highlighting immune markers that prevent symptomatic SARS-CoV-2 infection.

Abstract

Israeli Ministry of Health.

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Cite This Study

Regev‐Yochay et al. (2023) studied this question.

synapsesocial.com/papers/69dc48e08bac30e30e9f57dc https://doi.org/10.1016/s2666-5247(23)00012-5

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Implication

Prospective cohort study observes correlates of protection in vaccinated household contacts, highlighting immune markers that prevent symptomatic SARS-CoV-2 infection.

Abstract

Israeli Ministry of Health.

Correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel (ICoFS): a prospective cohort study

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel (ICoFS): a prospective cohort study

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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