Why the study?
Does milnacipran cause disruptive effects on cognitive function and psychomotor performance compared to amitriptyline in healthy young and elderly volunteers?
Does milnacipran cause disruptive effects on cognitive function and psychomotor performance compared to amitriptyline in healthy young and elderly volunteers?
Milnacipran appears safe for cognitive and psychomotor function in both young and elderly healthy volunteers, unlike amitriptyline which causes significant impairment in the elderly.
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Supports milnacipran preference over amitriptyline in elderly to avoid cognitive impairment; confirms differential effects in randomized volunteer studies.
Hindmarch et al. (2000) studied this question.
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