L-type amino acid transporter (LAT) 1 expression in 18F-FET-negative gliomas

Although LAT1 is reported to mediate the uptake of ¹⁸F-FET into tumour cells, the levels of LAT1 expression do not correlate with the levels of ¹⁸F-FET uptake in IDH-mutant astrocytomas. In particular, the lack of tracer uptake in ¹⁸F-FET-negative gliomas cannot be explained by a reduced LAT1 expression. A higher LAT1 expression in IDH-mutant astrocytomas seems to be associated with a short PFS. Further studies regarding mechanisms influencing the uptake of ¹⁸F-FET are necessary.