How does right ventricular diastolic stiffness affect right atrial function and filling dynamics in patients with pulmonary arterial hypertension?
In PAH, severe RV diastolic stiffness impairs RV active filling and increases vena cava backflow, and often persists despite treatment unless afterload is significantly reduced.
In PAH, RA function is associated with changes in RV function. Despite increased RA stroke work, severe RV diastolic stiffness is associated with reduced RV active filling and increased vena cava backflow. In 50% of patients with high baseline Eed, diastolic stiffness remained high, despite treatment. A reduction in Eed coincided with a large reduction in afterload, increased RV active filling and decreased vena cava backflow.
Wessels et al. (Thu,) studied this question.
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